Heart burn, Benign gastric and Duodenal ulcers including those complicating NSAID therapy, Erosive esophagitis and for disorders associated with hypersecretion of gastric acid, such as the Zollinger-Ellison syndrome, H.  pylori   eradication.

Heart burn: 20 mg daily for 4-8 weeks. Benign gastric and duodenal ulcers including those complicating NSAID therapy : 20 mg daily for 4 weeks in duodenal ulceration or 8 weeks in gastric ulceration, in severe cases the dose may  be increased to 40 mg daily. Zollinger-Ellison syndrome : Initially 60 mg once daily; usual range 20-120 mg daily (above 80 mg in 2 divided doses). Larger doses of upto 180 mg daily in divided doses may be used or as prescribed by the physicians. Zollinger Ellison syndrome has been treated continuously with OME for more than five years. 

OME can delay the elimination of diazepam, phenytoin and warfarin. Reduction of warfarin or phenytoin dose may be necessary when OME is added to treatment. There is no evidence of an interaction with theophylline, propranolol or antacids. 

Omeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.

OME is well tolerated. Nausea, diarrhoea, abdominal colic, paresthesia, dizziness and headache have been stated to be generally mild and transient and not requiring a reduction in dosage. 

Avoid in pregnancy unless there is no safer alternative. Breast-feeding should be discontinued if the use of  OME is considered essential. 

Symptomatic response to therapy with OME does not preclude the presence of gastric malignancy.