Xioclon is indicated for the treatment of the following diseases
-Anxiety as well as panic disorder, with or without agoraphobia,
-Epilepsy and other seizure disorders
-Alone or as an adjunct in the management of myoclonic and akinetic seizures and petit mal variant (Lennox-Gastaut syndrome). 
 

The standard dose of clonazepam must be individually adjusted according to the patient's clinical response and tolerance of the drug. As a general rule, clonazepam is started with low single dose in a new patient. 
Adults: 1mg (elderly, 0.5 mg), initially at night for 4 nights, increased according to response over 2-4 weeks to usual maintenance dose of 4-8 mg usually at night (may be given in 3-4 divided doses if necessary). 
Children: Up to 1 year, initially 0.25 mg, increased as above to usual maintenance dose of 0.5-1 mg. 
1-5 years initially 0.25 mg, increased as above to 1-3 mg.
5-12 years, initially 0.5 mg, increased as above to 3-6 mg.

The CNS depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, anxiolytic agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors, tricyclic antidepressants and by other anticonvulsant drugs.

Clonazepam should not be used in patients with a history of sensitivity to benzodiazepine nor in patients with clinical or biochemical evidence of significant liver disease. It may be used in patients with open angle glaucoma who are receiving appropriate therapy but is contraindicated in acute narrow angle glaucoma.

The most frequently occurring side effects of Clonazepam are CNS depression, drowsiness, fatigue, dizziness, muscle hypotonia, co-ordination disturbance, hypersalivation in infants, paradoxical aggression, irritability and mental change.
 

The use of Clonazepam during pregnancy or lactation should be avoided. The drug should only be administered to pregnant woman if the potential benefits of the patients outweigh the risk of fetus. Nursing mothers must stop breast feeding while taking clonazepam or vice-versa

Although simultaneous administration of several anticonvulsants may be considered with clonazepam, such combined therapy may result in a increase of central depressant adverse effects. When used in patients in whom several different types of seizures co-exist, clonazepam may increase the incidence or precipitate the onset of generalized tonic-clonic seizures (grand mal).

Symptoms of Clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

· Store in cool & dry place, protect from light.   
· Keep out of reach of children.