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Clindamet (Clindamycin Hydrochloride)

COMPOSITION:

Clindamet 150 Capsule: Each capsule contains Clindamycin Hydrochloride USP equivalent to Clindamycin 150 mg.Clindamet 300 Capsule: Each capsule contains Clindamycin Hydrochloride USP equivalent to Clindamycin 300 mg.


PHARMACOLOGY:

Clindamycin is a lincosamide antibiotic. Clindamycin inhibits bacterial protein synthesis by binding to the 50s subunit of the ribosome. It has activity against aerobic gram-positive cocci, including: Staphylococcus aureus, Staphylococcus epidermidis (penicillinase and non-penicillinase producing strains), Streptococci, Pneumococci, anaerobic gram-negative bacilli including: Bacteroides species, Fusobacterium species. Anaerobic gram-positive non-spore forming bacilli including: Propionibacterium species, Eubacterium species, Actinomyces species, anaerobic and microaerophilic gram-positive cocci including: Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci, C. perfringens.


INDICATION:

Clindamycin has been shown to be effective in the treatment of the following infections when caused by susceptible anaerobic bacteria or susceptible strains of gram positive bacteria such as Streptococci, Staphylococci and pneumococci: upper respiratory tract infections, lower respiratory tract infections, skin and soft tissue infections, bone and joint infections, pelvic infections, intra-abdominal infections, septicema and endocarditis, dental infections. As an alternative therapy when used in combination with quinine or amodiaquine for the treatment of multi-drug resistant Plasmodium falciparum infection.
DOSAGE AND ADMINISTRATION:

Adults

Serious Infections: 150 mg - 300 mg every 6 hours.More severe infections: 300 mg - 450 mg every 6 hours.

Pediatric Patients

Serious Infections: 8 - 16 mg/kg/day divided into 3 or 4 equal doses. More severe infections: 16 - 20 mg/kg/day divided into 3 or 4 equal doses.

SIDE EFFECT:

The adverse effects have been reported with the use of Clindamycin are abdominal pain, oesophagitis and oesophagial ulcer, nausea, vomiting and diarrhea, pruritus, skin rashes and urticaria.


CONTRAINDICATION:

Clindamycin is contraindicated in patients previously found to be sensitive to Clindamycin or Lincomycin or any of the ingredients of this medicine.
PRECAUTIONClindamycin should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.


DRUG INTERACTION:

Clindamycin enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has beendemonstrated between Clindamycin and Erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.


USE IN PREGNANCY & LACTATION:

Pregnancy category B: Clindamycin crosses the placenta in humans. After multiple doses, amniotic fluid concentrations were approximately 30% of maternal concentrations. Clindamycin should be used in pregnancy only if clearly needed.Lactation: Clindamycin has been reported to appear in breast milk. Therefore, it is not recommended for nursing mothers if not clearly needed.


USE IN NEWBORN AND INFANT

When Clindamycin is administered to newborns and infants (Birth to 1 years) , appropriate monitoring of organ system functions is desirable.
OVERDOSAGEOverdosage with orally administered Clindamycin has been rare. Adverse reactions similar to those seen with normal doses can be expected. However, unexpected reactions could occur. Haemodialysis and peritoneal dialysis are not effective in removing Clindamycin from the serum. Overdosage should be treated with simple gastric lavage. No specific antidote is known.


STORAGE:

Store in cool & dry place, protected from light.· Keep out of reach of children.


PACKAGING:

Clindamet 150 Capsule: Each box contains 2x10's/3x10's/4x8's/4x7's/5x6's in Alu-Alu pack.Clindamet 300 Capsule: Each box contains 2x10's/3x10's/4x8's/4x7's/5x6's in Alu-Alu pack.

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